It is important to note that once all relevant data, including weight, parity, smoking status, β-hCG, and PAPP-A, are entered into the T1 software PRISCA (PerkinElmer) and LifeCycle (Revvity), the MoM values for β-hCG and PAPP-A are adjusted accordingly, ensuring that factors such as smoking, obesity, or previous pregnancies do not influence the corrected MoM values. The gene discussed is PAPPA; the disease is obesity due to melanocortin 4 receptor deficiency.