SFTPD and acute respiratory distress syndrome: They found that the serum concentrations of SP-D and sRAGE were both significantly increased in ARDS patients with pulmonary superinfections compared to ARDS patients who did not develop pulmonary superinfections (p = 0.0397 and p = 0.049, respectively), emphasizing that tracking dynamic biomarker changes over time offers improved prognostic insights, particularly in cases complicated by pulmonary superinfections [18].