AGER and acute respiratory distress syndrome: One of the earliest studies on the association between sRAGE and 28-day mortality in ARDS was conducted in 2008 by Calfee et al., identifying sRAGE as a potential independent predictor of 28-day mortality (OR for death 1.38 (95% CI 1.13 to 1.68) per 1 log increment in RAGE; p = 0.002).