SIRT1 and aneurysm: In the context of aneurysms, similar to how METTL14 promotes DGCR8-mediated processing of pri-miR-19a in atherosclerosis [69], METTL3-dependent m6A methylation promotes primary miR-34a maturation through DGCR8, leading to decreased SIRT1 expression and an aggravated aneurysm formation [68].