IL6 and hereditary elliptocytosis: A systematic literature review and meta-analysis comparing data published up to June 2024 revealed that, besides a noticeable increase in blood ammonia, significant alterations were also found for other analytes in HE patients, including serum creatinine, albumin, sodium, and the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNFα) [25].