Important molecules, pathways, the nuclear transcription factor kappa B, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway, and inflammatory cytokines (interleukins such as IL-6, IL-18, and tumor necrosis factor-alpha—TNF-α), Intercellular Adhesion Molecule 1, are implicated in both systemic and local renal inflammation in DKD [68,69]. This evidence concerns the gene TNF and diabetic kidney disease.