The ability of VIP (vasoactive intestinal peptide) to reduce hyperglycemia-induced increases in TNF-α, VEGF, ALX/FPR2, and GPR32 in human retinal vascular endothelial cells can be attributed to its ability to enhance resolvin D1 formation [104,105], suggesting that anti-inflammatory bioactive lipids are crucial to restore normal homeostasis. The gene discussed is VIP; the disease is Hyperglycemia.