RvD1 impaired paracrine of cancer-associated fibroblast (CAF)-derived cartilage oligomeric matrix protein (COMP) by targeting formyl peptide receptor 2 (FPR2)/reactive oxygen species (ROS)/forkhead box M1 (FOXM1) signaling to repress epithelial–mesenchymal transition (EMT) and cancer stemness in hepatocellular carcinoma (HCC). This evidence concerns the gene COMP and cancer.