In our experiments, we used both a CB1 receptor agonist (oleamide) and antagonist (AM 251), as well as a CB1/CB2 receptor mixed agonist (WIN 55,212) and CB2 receptor agonist (JWH 133) and antagonist (AM 630), to evaluate the direct influence of ECS on the anxiety-related action in mice. Here, CNR1 is linked to Anxiety.