PTPN1 and acute promyelocytic leukemia: In vitro nematocidal activity towards Meloidogyne incognita larvae: 95% mortality at 0.5% concentration after 48 h. In vitro antiparasitic activity towards Leishmania mexicana promastigotes: IC50 = 2.52 ± 0.08 μM. In vitro protein tyrosine phosphatase 1B inhibition assay: IC50 = 5.1 μM [84]. In vitro cytotoxic activity towards HL-60 human promyelocytic leukemia cells (JCRB0085): IC50 = 1.71 ± 0.10 μM. In vitro anti-inflammatory activity (inhibition of LPS-induced NO production in BV-2 cells): IC50 > 3 μM.