CES1 and obesity due to melanocortin 4 receptor deficiency: In addition, a recent in silico study has evaluated 20 selected constituents of L. camara as potent inhibitors of the human enzymes acetylcholinesterase (hAchE), carbonic anhydrase II (hCA-II), and carboxylesterase 1 (hCES-1), which are pharmacological targets for the treatment of neurodegenerative diseases, glaucoma, obesity, and type 2 diabetes [171].