Moreover, it was revealed that schizophrenia-like behaviors observed in Bdnf-e6-/- mice (promoter VI mutant mice) exposed to postnatal stress improved after treatment with an antagonist for glucocorticoids or an agonistic antibody for TrkB, suggesting the involvement of both stress and the BDNF/TrkB system in the pathogenesis of schizophrenia [16]. Here, BDNF is linked to schizophrenia.