The enriched pathways suggested that PMFs may intervene in CNS disorders through multiple pathways, including metabolism (such as metabolic pathways, nitrogen metabolism, steroid hormone biosynthesis, ovarian steroidogenesis), infection and immunity (such as human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, human cytomegalovirus infection), and signal transduction (PI3K-Akt, MAPK, Rap1 signaling pathway, FoxO signaling pathway, phospholipase D signaling pathway, calcium signaling pathway, neuroactive ligand-receptor interaction). The gene discussed is AKT1; the disease is central nervous system disorder.