The model, incorporating smoking, the intake of SSRI/MAOI medications, the risk of frailty syndrome, loss of appetite according to CNAQ and SNAQ, ASMI, VAT, and CCK-8, achieved a high level of accuracy in predicting malnutrition risk, with an AUC of 0.84 (95% CI: 0.77–0.90). The gene discussed is CCK; the disease is nutritional deficiency disease.