MAPK8 and allergic disease: In vitro experiments using human mast cells (HMC-1) demonstrated that quail egg albumen effectively suppressed the release of allergy-related mediators such as β-hexosaminidase, histamine, tryptase, and pro-inflammatory cytokines while also upregulating IL-10: mechanistically, quail egg albumen down-regulated calcium-related proteins (TRPC1, Orai1, STIM1, PLC-γ, and IP3R) and inhibited key signaling pathways (PAR-2, JNK, IKKα, p50, and p65), suggesting its potential in modulating allergic responses [39].