Afterward, we decided to investigate the effect of IMQ on the Mφ expression of the IL-23, IL-6, and IL-8 cytokines, as well as that of the CCL-20 chemokine, known for being produced at a high level by macrophages in the psoriatic skin microenvironment and for being involved in the hyperproliferative response of the keratinocytes in psoriasis. This evidence concerns the gene IL6 and psoriasis.