A meta-analysis of 19 Randomized Controlled Trials (RCTs) [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31] to determine whether diet improves insulin sensitivity (Si) in women with PCOS indicated that dietary intervention could be beneficial in the management of PCOS [32]. This evidence concerns the gene INS and polycystic ovary syndrome.