PLOD1 and polycystic ovary syndrome: In a randomized parallel trial by Mei et al., 2022 [102], overweight women with PCOS who consumed a calorie-restricted dietary pattern consisting of a MED diet plus a low-carbohydrate diet (<20% carbohydrate, up to 100 g carbohydrate) for 12 weeks showed significant decreases in anthropometric parameters, glucose control (FBG, FBI, HOMA-IR, and QUICKI), lipids (TG, TC, and LDL-C), and gonadal parameters (LH and LH/FSH), compared with the control low-fat diet (<40 g fat (<30% from total daily energy intake), up to 10% SFA).