Finally, the study conducted by Verier et al. [134] showed that among children carrying the high-risk obesity-related phenotype Pro12Ala of the PPAR-γ gene BMI, waist circumference and skinfold thickness all decreased with an increased duration of breastfeeding compared to children who were formula-fed, thus suggesting that breastfeeding might modulate PPAR-γ gene transcriptional activity among individuals carrying the Pro12Ala allele. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.