Its inhibition results in less methylation of developmental-related gene promoters in the CpG islands, such as FOXP3 (regulatory T-cell master transcription factor), insulin (INS), insulin-linked growth factor 1 (IGF-1), or fat mass- and obesity-associated gene (FTO), and, consequently, greater expression of the latter [123,131,132]. The gene discussed is INS; the disease is obesity disorder.