The mRNA expression level of GPR146 was very low (<1 RPKM in all locations) throughout the intestines of individuals with and without type 2 diabetes with similar expression patterns (Figure 3A, Tables S11 and S12); no significant differences between the duodenum and other small intestinal locations were observed after adjusting for multiple testing (Table S13). Here, GPR146 is linked to type 2 diabetes mellitus.