INS and Insulin resistance: Insulin and lipid peroxidation have an inverse relationship, meaning that high levels of insulin can lead to decreased lipid peroxidation, while conditions causing insulin resistance often result in increased lipid peroxidation, contributing to further insulin resistance through damage to cellular components involved in insulin signaling pathways; essentially, when insulin signaling is impaired, the body can experience increased oxidative stress and lipid peroxidation, creating a vicious cycle.