In a real-life population, when analyzing those patients, with a first major bleeding event while on direct Factor Xa inhibitors, from the BIG-PAC® database in Spain, mean age was 78 years, 61% of patients were women, most had atrial fibrillation (78%) and patients presented with many comorbidities (79% had hypertension, one third type 2 diabetes, and 24% heart failure) [24]. Here, F10 is linked to Hypertension.