For example, among patients with a first major bleeding event taking Factor Xa inhibitors from the BIG-PAC® database, 4.26% of patients died at the end of the first major bleeding event, 70.0% in case of trauma-related bleeding, 28.13% after intracranial hemorrhage, and 2.15% after gastrointestinal bleeding [24]. This evidence concerns the gene F10 and intracranial hemorrhage.