For example, in the case of patients with atrial fibrillation, in clinical trials comparing direct Factor Xa inhibitors vs. warfarin, the mean age ranged between 70 and 73 years, 35–40% of patients were women, 90–94% had arterial hypertension, 25–40% type 2 diabetes and 35–63% heart failure [32,33,34]. Here, F10 is linked to heart failure.