CFTR and pancreatitis: They discovered that (i) pancreatitis-inducing factors such as bile acids, fatty acids, and ethanol dose-dependently deteriorate pancreatic ductal secretion via mitochondrial damage and calcium overload [16,17], (ii) the function of CFTR is strongly inhibited by alcohol and fatty acids [18], and (iii) the restoration of ductal function by ATP or MPTP inhibitors decrease the severity of acute pancreatitis [19].