Large prospective studies are certainly needed to establish structured and evidence-based insulin titration protocols (regarding both basal and bolus insulin doses) to avoid hypoglycemia, ketosis and DKA/euDKA in T1D patients using semaglutide and tirzepatide in addition to insulin therapy (administered either via insulin pens or via insulin pumps and AID systems) and exhibiting different degrees of glucose control, excess body weight and/or insulin resistance. This evidence concerns the gene INS and Insulin resistance.