Sharma et al. [129] first described the case of a 36-year-old woman with T1D on a closed-loop insulin infusion system (Tandem t:slim X2 insulin pump with Control-IQ technology; Tandem Diabetes Care, Inc., San Diego, CA, USA) and tirzepatide therapy who experienced DKA after closed-loop insulin infusion set failure in the setting of volume depletion. The gene discussed is INS; the disease is type 1 diabetes mellitus.