INS and type 1 diabetes mellitus: Navodnik et al. [110] conducted the ENDIS study (Endothelium dysfunction assessment study), a 12-week intervention, prospective, randomized, single-center, controlled clinical study that enrolled 91 adult patients with long-standing T1D on insulin therapy [either with multiple daily injection (MDI) insulin therapy or continuous subcutaneous insulin infusion (CSII)], all using CGM systems.