INS and type 2 diabetes mellitus: Key diagnostic criteria for LADA include the following: (a) adult-onset diabetes (age greater than 30 years at the time of diagnosis); (b) presence of islet autoantibodies (with GADA being considered the predominant islet autoantibodies and the most sensitive laboratory marker of LADA); and (c) absence of insulin requirement for at least 6 months after the disease diagnosis [71].