A meta-analysis showed varying levels of success in improving live birth rates and reducing miscarriage rates through IVIG intervention in aPL-positive patients with recurrent miscarriage, with this effect being more prominent and statistically significant in aPL-positive patients in combination with systemic lupus erythematosus or other similar autoimmune diseases, but the IVIG-treated group exhibited a higher incidence of preterm labor [58]. This evidence concerns the gene FASLG and systemic lupus erythematosus.