In a large Chinese cohort composed of 192 APS patients, 90 seronegative APS patients, 193 autoimmune disease controls, and 120 healthy controls, ten aPLs were tested, including five non-criteria aPLs: aPS/PT IgG/IgM, aCL IgA, aβ2GPI IgA, and anti-β2GPI Domain IgG. This evidence concerns the gene ACLY and autoimmune polyendocrinopathy.