PIK3CA and angiosarcoma: Contrarily, angiosarcoma cells evade apoptosis, mainly due to increased expression of carcinogenesis drivers such as phosphatidylinositol-4, 5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphorylated mitogen-activated kinase-like protein (pMAPK), and tumor protein p53 (TP53), and decreased expression of phosphatase and tensin homolog (PTEN), a major regulator of the PI3K/Akt pathway [19].