Despite these similarities, CCS possesses unique molecular features, such as t(12;22)(q13;q12) translocation, that fuses EWSR1 on chromosome 22 with ATF1 (member of the CREB transcription factor family on chromosome 12), a chromosomal rearrangement absent in melanoma and in other soft tissue sarcomas [5]. The gene discussed is ATF1; the disease is melanoma.