To substantiate this theory, a wide panel of inflammatory markers should be evaluated, encompassing both pro- and anti-inflammatory cytokines and assessing viral infection markers (through specific PCR tests, indirect markers like IFN-α and IFN-γ; [9,57] as well as general allergic responses (e.g., non-specific IgE, tryptase, blood smear). The gene discussed is IGHE; the disease is viral infectious disease.