Moreover, early studies using a mouse model of SCD showed that the inhibition of lysine-specific demethylase-1 (LSD1) and mammalian target of rapamycin (mTOR) via RN-1 and sirolimus, respectively, reduced mitochondrial retention with a concomitant reduction in ROS in RBCs from SCD mice [110]. This evidence concerns the gene KDM1A and Schnyder corneal dystrophy.