DYSF gene mutations lead to limb girdle muscular dystrophy [57], and TRPV4 may be involved in the physiological protective function during hypoxic exercise [58], the data from this study show a decreasing trend in plasma exosomes, suggesting that muscle damage caused by horse racing may be related to changes in the expression of these two genes, and may be a potential therapeutic target. Here, DYSF is linked to limb-girdle muscular dystrophy.