IL6 and rheumatoid arthritis: Considering that exosomes can participate in signal pathway regulation [62], that the metabolism of phosphatidylcholine [63] and glycerophospholipids in exosomes is involved in signal pathway regulation, and that glycerophospholipid metabolism is involved in rheumatoid arthritis pathogenesis by regulating the IL-6/JAK signaling pathway, this may be related to the impact of exercise on the function of the sphingomyelin signaling pathway in skeletal muscle [64].