CHD4 is suggested to play an oncogenic role by modulating the chromatin accessibility of the promoter region by promoting DNA hypermethylation as well as repressing the transcription of several CRC-relevant tumor suppressor genes, like E-cadherin (CDH1), WNT inhibitory factor 1 (WIF1), TIMP metallopeptidase inhibitor 2 (TIMP2), TIMP metallopeptidase inhibitor 3 (TIMP3), mutL homolog 1 (MLH1), cyclin-dependent kinase inhibitor 2A (CDKN2A), secreted frizzled-related protein 4 (SFRP4), and secreted frizzled-related protein 5 (SFRP5) [1,38]. This evidence concerns the gene CDKN2A and colorectal carcinoma.