Knockdown of CHD4 reduces the expression of multi-drug efflux transporter ATP-binding cassette ABCB1 or multi-drug resistance-1 (MDR1) in ovarian cancer cell lines (TOV21G and JHOG5); this suggests that CHD4 modulates the function of MDR1 and plays a vital role in ovarian cancer [102,103]. The gene discussed is CHD4; the disease is ovarian carcinoma.