Recently, the variants RASSF1 rs2073498, SERPINE rs1799889, EFNA1 rs12904, and RAD51 rs1801320 have been analyzed in cancer, getting variable results in multiple ethnicities [11,16,20,22,34,39,44,45,53,54,60] Therefore, in this study, we examined for the first time in the Mexican population the genotype distribution of four variants, rs2073498, rs1799889, rs12904, and rs1801320, in the RASSF1, SERPINE, EFNA1, and RAD51 genes. This evidence concerns the gene RASSF1 and cancer.