A comprehensive evaluation of genotype–phenotype correlations revealed that although there may not be a direct link between the genotype and the severity of the retinal disease phenotype, RPGR carriers with disease-causing variants at the ORF15 site appeared to have poorer clinical outcomes, particularly concerning LLVA and retinal thickness, compared to carriers with exon 1–14 variants, irrespective of age. This evidence concerns the gene RPGR and Abnormal retinal morphology.