COL4A5 and atrial fibrillation: In the general population (gnomAD), the allele frequency of the COL4A5:c.1871G>A variant was 0.00004629, with no homozygous occurrences reported, and it was the most frequent (AF = 0.00004833) in the European (non-Finnish) population, including 23 hemizygotes (population Grpmax Filtering AF with 95% confidence).