Disease-causing variants encompassing eight genes encoding members of this family have consistently been associated with syndromic neurodevelopmental disorders (NDDs) (HNRNPH1, MIM 601035; HNRNPH2, MIM 300610; HNRNPK, MIM 600712; HNRNPR, MIM 607201; HNRNPU, MIM 602869; HNRNPQ, MIM 616686; HNRNPG, MIM 300199; HNRNPC, MIM 164020) [3,4,5,6,7,8,9,10,11,12]. The gene discussed is HNRNPC; the disease is neurodevelopmental disorder.