PSMB5 and fragile X-associated tremor/ataxia syndrome: The fragile X premutation is associated with an elevated risk of developing either fragile X-associated primary ovarian insufficiency (FXPOI, OMIM# 311360), resulting in reproductive issues and premature menopause [65], fragile X-associated tremor/ataxia syndrome (FXTAS, OMIM# 300623), a progressive neurodegenerative disorder occurring later in life [34], or fragile X-associated neuropsychiatric disorders (FXANDs), most often neurodevelopmental, anxiety or depressive disorders [66].