Frazier-Bowers and colleagues [25] examined families with a clinical diagnosis of PFE, focusing on specific candidate genes potentially involved in tooth eruption, such as POSTN, Runt-Related Transcription Factor 2 (RUNX2), Amelogenin-X-linked (AMELX), and Ameloblastin (AMBN). This evidence concerns the gene RUNX2 and primary failure of tooth eruption.