In this context, we selected some of the identified lncRNAs (NRON, EMX2OS, ZFAS1, HAR1B, TUG1, MALAT1, H19, MEG3, HOTTIP, GAS5, HOTAIR) in order to assess the effect of single versus combined treatments of several anticancer drugs (Carboplatin/CPt, Paclitaxel/Pxl), monoclonal antibodies (Avastin/Ava/Bevacizumab), or natural compounds (Quercetin/Qct) with established epigenetic modulators like suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor (HDACi), or 5-Azacytidine (5-Aza C), a demethylating agent, on the U87-MG glioblastoma cell line. The gene discussed is HOTAIR; the disease is glioblastoma.