ANKRD11 and KBG syndrome: Using two male LCLs established from the patients with KBG syndrome carrying intragenic pathogenic ANKRD11 variants, and two male control LCLs, we identified differentially expressed genes (DEGs) (total 628 genes: 217 upregulated and 411 downregulated) in LCLs carrying pathogenic ANKRD11 variants (FDR < 0.05) (Supplementary Table S2).