The major causative genes of non-syndromic HL in Japanese patients are GJB2 (12.9%), SLC26A4 (3.4%), and CDH23 (3.4%), whereas the ratio shifts to GJB2 (7.8%), STRC (3.4%), and KCNQ4 (2.2%) among patients classified with mild-to-moderate HL [3]. This evidence concerns the gene GJB2 and Hodgkins lymphoma.