NTRK1 and cardiac hypertrophy: In normal and cancer cell lines, research has shown that ATIP3 and ATIP1 effectively suppress cell proliferation by inhibiting the growth factor-induced autophosphorylation of receptor tyrosine kinases and extracellular-regulated kinase and by lowering the reactive oxygen species levels in the mitochondria, which is an independent factor for cardiac hypertrophy [19,20,21].