MTUS1 and advanced heart failure: Furthermore, it was shown that the MTUS1 genetic variant c.2617A>C (p. Asn873His) in HEK-293 cell lines reduces the extent of noncompaction through enhanced polarization and exerts a protective effect in the development of LVNC; since microtubule overstabilization is also observed in advanced heart failure, variations in MTUS1 might have not yet described roles in cardiac functioning [3,5].