Immunefluorescence studies between untreated tumor cells (Figure 3E) and GE-treated cells (Figure 3F) revealed a twofold and significantly increased Caspase-8 signal intensity (Supplementary Figure S3B) associated with a significant increased colocalization of Integrin β1 and Caspase-8 (white boxes in E/F and Supplementary Figure S3C). This evidence concerns the gene CASP8 and neoplasm.