The top five significantly (using adjusted p value < 0.05) enriched terms were the following: haemostasis (SERPINA5, SOD1, IGLL1, FAM3C, EGF, and SERPINC1) as the highest mechanism in the pathogenesis of CKD, the intrinsic pathway of fibrin clot formation (SERPINA5 and SERPINC1), the common pathway of fibrin clot formation (SERPINA5 and SERPINC1), keratin sulphate biosynthesis (B4GAT1 and OMD), and regulation of insulin growth factor 1 (IGF-1) transport and uptake by insulin growth factor binding proteins (HSP90B1, IGFBP6, and SERPINC1). The gene discussed is IGFBP6; the disease is occult macular dystrophy.