ON study resulted in the following candidate biomarker genes related to AA (AAGs): IGF1R, MXI1, RB1, PPARA, NFE2L2, STAT5B, FOS, PRKCD, YWHAZ, HTT, MAPK9, HSPA9, SDHC, PRKDC, and PDPK1. However, the differential expression of IGF1R, MXI1, PPARA, YWHAZ, and MAPK9 correlated with ND progression, and it was not possible to justify AAGs as MBMs due to an insufficient sample size [73]. This evidence concerns the gene PPARA and Norrie disease.