To evaluate the functional contribution of GluN2B subunits to the DL-TBOA-induced memory impairment, we next performed bilateral injections of DL-TBOA and ifenprodil (12 nmol), a selective GluN2B antagonist, into the hippocampus of C57BL/6J mice 40 min before the encoding phase of the Y-maze paradigm (Figure 4a). Here, GRIN2B is linked to memory impairment.