Liver fat was positively associated with Prenylcysteine Oxidase 1 (PCYOX1, involved in the regulation of adipogenesis) and Heat shock protein 90 Alpha Family Class A Member 1 [HSP90AA1 involved in lipid metabolism and metabolic-dysfunction-associated steatotic liver disease (MASLD) progression]. The gene discussed is HSP90AA1; the disease is metabolic dysfunction-associated steatotic liver disease.