In DKD, reduced expression of the cholesterol efflux mediators ABCA1, ABCG1, and apoE correlates with the progression of diabetic nephropathy and deterioration of the estimated glomerular filtration rate (eGFR) [110], suggesting that the development of DKD is associated with reduced HDL-mediated cholesterol efflux [111]. This evidence concerns the gene ABCA1 and diabetic kidney disease.