In DKD, reduced expression of the cholesterol efflux mediators ABCA1, ABCG1, and apoE correlates with the progression of diabetic nephropathy and deterioration of the estimated glomerular filtration rate (eGFR) [110], suggesting that the development of DKD is associated with reduced HDL-mediated cholesterol efflux [111]. The gene discussed is ABCG1; the disease is diabetic kidney disease.