CD274 and colorectal cancer: Benzosceptrin C: From a drug panel screen of 300 Chinese traditional medicines using the RKO colorectal cancer cell line, benzosceptrin C (10 μM, 24 h) was identified to inhibit the activity of zDHHC3 which hindered the palmitoylation of a downstream target, namely programmed cell death ligand-1 (PD-L1) [201].