ZDHHC13 and Anxiety: Further evidence of the contribution of the loss of zDHHC13 to mitochondrial function arises from in vivo studies using a luc mouse model that is deficient in zDHHC13, which is characterized by reduced S-palmitoylation on dynamin-related protein 1 (Drp1, a mitochondrial fission protein that is a defined substrate of zDHHC13), in the context of bioenergetics in brain tissue as well as anxiety-induced behavioral changes [123].