In psoriasis, several skin barrier function proteins are located within or nearby GWAS sites including claudin-5, claudin-6, claudin-14, zonula occludens-1 (ZO-1), connexin 26 (Cx26), nectins, desmosomal plaque proteins (i.e., plakophilins, plakoglobin, envoplakin, and periplakin), and envelope proteins (i.e., filaggrin, keratinocyte proline-rich protein, corniferin, small proline-rich proteins, involucrin, loricrin, and PADi3). Here, GJB2 is linked to psoriasis.