PLSCR1 and lung cancer: PLSCR1 is an interferon-inducible (IFN) gene [134,172] that is localized to lipid rafts [170,173]; the loss of PLSCR1 using an shRNA-based approach led to a loss of cellular protection to the virulence factor, α-toxin, which is derived from Staphylococcus aureus, in A549 lung cancer cells [174].