The roles can be described as (1) maintaining immune balance by suppressing excessive inflammation and preventing autoimmunity through mechanisms such as cytokine production (e.g., IL-10, TGF-β), and modulation of antigen-presenting cells (APCs); and (2) limiting antitumor immunity by creating an immunosuppressive tumor microenvironment, suppressing cytotoxic T-cells, and promoting tumor immune evasion. The gene discussed is TGFB1; the disease is neoplasm.