PNPLA3 and steatosis: Finally, the NASH ClinLipMet Score is a metabolic-based combination score that integrates the following five metabolites, namely glycine, isoleucine, glutamate, lyso-phosphatidylcholine 16:0, and phosphoethanolamine 40:6, as well as the PNPLA3 genotype and clinical variables, showing promise in distinguishing steatohepatitis from steatosis with an AUROC of 0.87 [216].