Additionally, comprehensive genetic investigations conducted in murine models and primary hepatocyte cultures indicate that the lncRNA known as the regulator of hyperlipidemia (lncRHL) serves to activate the lncRHL/heterogeneous nuclear ribonucleoprotein U (hnRNPU)/brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like protein 1 (BMAL1)/microsomal triglyceride transfer protein (MTTP) signaling pathway, thereby unveiling novel molecular mechanisms that regulate lipid homeostasis within hepatic and circulatory systems [157]. Here, HNRNPU is linked to hyperlipidemia.