Moreover, Kozumi et al., after performing a transcriptomic analysis, illustrated that serum thrombospondin 2 expression (TSP-2) encoded by the THBS2 gene was upregulated in NASH and that levels of TSP-2 were markedly linked to progressive fibrosis in individuals with NAFLD [122]. This evidence concerns the gene THBS2 and metabolic dysfunction-associated steatotic liver disease.