RNA microarrays have revealed that there is an upregulation of genes related to lipid metabolism, acute phase regulators of insulin sensitivity, cellular division, DNA and tissue repair, extracellular matrix organization, immune function, cellular adhesion and migration, signal transduction, P53 signaling, and cancer progression in NAFLD and NASH [46,107,108,109,110,111,112]. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.