The expression and levels of notable genes, such as ITGBL1, cFAP, SPP1 (which encodes osteopontin), STMN2 [which encodes SCG10 (Superior Cervical Ganglia-10 Protein)], and DPT, are elevated in accordance with the increase in liver fibrosis stages [125,126,127,128,129], while the expression levels of S100A6 are heightened in primary human HCC and cholangiocarcinoma [121,130]. The gene discussed is SPP1; the disease is cholangiocarcinoma.