Moreover, Kozumi et al., after performing a transcriptomic analysis, illustrated that serum thrombospondin 2 expression (TSP-2) encoded by the THBS2 gene was upregulated in NASH and that levels of TSP-2 were markedly linked to progressive fibrosis in individuals with NAFLD [122]. Here, THBS2 is linked to metabolic dysfunction-associated steatohepatitis.