As hepatoma cancer cells can modulate the antitumour immune response in direct contact with immune cells, we measured the surface expression of stimulatory (CD70, TNFRSF9, ICOS-L, and OX40-L) and suppressive (PD-L1, PD-L2, and HVEM) immune checkpoint molecules (ICMs) on the tumour cells after the 48 h of continuous incubation with examined NPs (55.6 μg/mL) and subsequently NIR exposition (Figure 7D and Figure 8D). Here, PDCD1LG2 is linked to neoplasm.