IGHE and allergic disease: Specifically, mouse models utilizing FAHF-2 prevented histamine release and anaphylaxis, with decreased peanut-specific IgE, Th2 cytokines expression including IL-4, IL-5, and IL-13, and mast cell degranulation, and coincided with the increase in peanut-specific allergy-protective IgG2a and cytokine expression including IFNY and IL-10 [165,166,167,168].